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Parameters for CaRegulation (Pathway Number 86)
Pathway Basic Parameters
| Pathway Name||CaRegulation|
| Pathway Entry Number || 86|
| Accession Number ||16|
| Accession Name ||Synaptic_Network|
| Species ||Generic mammalian|
| Tissue ||Neuronal|
| Related Pathways ||11,
| Notes|| This simple implementation of Ca regulation includes three compartments: the extracellular, the intracellular, and the Ca stores. Pumps maintain the Ca levels in cytoplasm (pumping out to the extracellular space and into the stores). Leak channels from the stores and extracellular space balance it out. Finally, the IP3 receptor and the capacitive entry channel respond to stimuli of various kinds. One clear direction for further work is to incorporate various calcium buffering proteins such as calsequestrin into the model. Primary reference is from the book Receptors: Models for binding, trafficking and signaling, by Lauffenburger and Linderman, OUP, 1993, Ch 5, around pg 200. There is extensive reference to a submitted paper by Mahama and Linderman, whose published version appears to be Mahama and Linderman 1994 Biophys J 67(3):1345-1357 This model is a little artificial on the IP3R kinetics and does not include the Ca influence on IP3R.
|This pathway is part of accession 16 and is completely specified in the file acc16.g.|
There is no separate files for just this pathway.
|Native Format (GENESIS format)|| acc16.g |
|GENESIS Format (Annotated version)|| Anno_acc16.g |
Pathway Detail Molecule List Enzyme List Reaction List
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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