| | PP1_CaMKII_PSDPP1_CaMKII_PSD |
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Molecule List for pathway PP1_PSD (Pathway Number 286) | Name | Initial Conc. (uM) td> | Volume (fL) | Buffered | 1 | I1 | 4 | 0.01 | No | | I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-compet, so it just turns the enz off without interacting with the binding site. Cohen et al ann rev bioch refer to results where conc is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM. | 2 | I1* | 0 | 0.01 | No | | Dephosph is mainly by PP2B | 3 | PP1-active_PSD | 4 | 0.01 | No | | Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM in their study. Here we use about 2x this level because of high PSD levels of many proteins. In this model of weak coupling, this pool only acts on the AMPARs in the membrane, and not on CaMKII. | 4 | PP1-I1 | 0 | 0.01 | No | | | 5 | PP1-I1* | 0 | 0.01 | No | | |
Pathway Details Molecule List Enzyme List Reaction List
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