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Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering.   indicates that ordering is done according to ascending or descending order.Entries are color tagged depending on Network  or Pathway  |
| Pathway Name Pathway No. | Accession Name Accession No. | Accession Type | Pathway statistics | caregulation statistics | Source Entry Date | ||||||||||
| 1 | CaRegulation Pathway No. 149 | NonOsc_Ca_ IP3metabolism Accession No. 31 | Network | Molecule = 22 Enzyme = 1 Reaction = 12 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-04-03 00:00:00 | |||||||||
| Related Pathway: 11, 86, 110, 132, 170 | |||||||||||||||
| Ca Regulation model used for the IP3metabolism network. It includes 3 compartments: extracellular, intracellular and the Ca stores. Ca pumps that pump out Ca from cytoplasm to extracellular space and into stores, are balanced by leak channels from the stores and extracellular space. The IP3 receptor and capacitative entry channels drive Ca under influence of different stimuli. Model includes the Ca buffer - Calsequestrin in the stores. The model is a little artificial on IP3R kinetics, and does not include the influence of Ca on IP3R. | |||||||||||||||
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| 2 | CaRegulation Pathway No. 170 | Osc_Ca_ IP3metabolism Accession No. 32 | Network | Molecule = 16 Enzyme = 1 Reaction = 9 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-04-03 00:00:00 | |||||||||
| Related Pathway: 11, 86, 110, 132, 149 | |||||||||||||||
| Modified Ca Regulation model for the IP3 metabolism network. This model is used with the Othmer-Tang model for IP3 receptor kinetics, to generate cytosolic Ca oscillations. Channel kinetics of the IP3 receptor, ER-leak, ER-pump (or CaATPase) and Capacitative Ca entry have been modified to allow for Ca oscillations characterized in the Othmer-Tang model (Tang et al, Biophys J 70, 1996: 246-63). Kinetics of store Ca buffering by Calsequestrin have not been changed. | |||||||||||||||
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| 3 | CaRegulation Pathway No. 132 | Osc_Ca_ IP3metabolism Accession No. 24 | Network | Molecule = 16 Enzyme = 1 Reaction = 9 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-01-08 00:00:00 | |||||||||
| Related Pathway: 11, 86, 110, 149, 170 | |||||||||||||||
| Modified Ca Regulation model for the IP3 metabolism network. This model is used with the Othmer-Tang model for IP3 receptor kinetics, to generate cytosolic Ca oscillations. Channel kinetics of the IP3 receptor, ER-leak, ER-pump (or CaATPase) and Capacitative Ca entry have been modified to allow for Ca oscillations characterized in the Othmer-Tang model (Tang et al, Biophys J 70, 1996: 246-63). Kinetics of store Ca buffering by Calsequestrin have not been changed. | |||||||||||||||
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| 4 | CaRegulation Pathway No. 110 | NonOsc_Ca_ IP3metabolism Accession No. 23 | Network | Molecule = 22 Enzyme = 1 Reaction = 12 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-01-07 00:00:00 | |||||||||
| Related Pathway: 11, 86, 132, 149, 170 | |||||||||||||||
| Ca Regulation model used for the IP3metabolism network. It includes 3 compartments: extracellular, intracellular and the Ca stores. Ca pumps that pump out Ca from cytoplasm to extracellular space and into stores, are balanced by leak channels from the stores and extracellular space. The IP3 receptor and capacitative entry channels drive Ca under influence of different stimuli. Model includes the Ca buffer - Calsequestrin in the stores. The model is a little artificial on IP3R kinetics, and does not include the influence of Ca on IP3R. | |||||||||||||||
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| 5 | CaRegulation Pathway No. 86 | Synaptic_ Network Accession No. 16 | Network | Molecule = 11 Enzyme = 1 Reaction = 4 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-12-12 00:00:00 | |||||||||
| Related Pathway: 11, 110, 132, 149, 170 | |||||||||||||||
| This simple implementation of Ca regulation includes three compartments: the extracellular, the intracellular, and the Ca stores. Pumps maintain the Ca levels in cytoplasm (pumping out to the extracellular space and into the stores). Leak channels from the stores and extracellular space balance it out. Finally, the IP3 receptor and the capacitive entry channel respond to stimuli of various kinds. One clear direction for further work is to incorporate various calcium buffering proteins such as calsequestrin into the model. Primary reference is from the book Receptors: Models for binding, trafficking and signaling, by Lauffenburger and Linderman, OUP, 1993, Ch 5, around pg 200. There is extensive reference to a submitted paper by Mahama and Linderman, whose published version appears to be Mahama and Linderman 1994 Biophys J 67(3):1345-1357 This model is a little artificial on the IP3R kinetics and does not include the Ca influence on IP3R. | |||||||||||||||
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| 6 | CaRegulation Pathway No. 11 | fig2_egfr Accession No. 1 | Network | Molecule = 11 Enzyme = 1 Reaction = 4 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||
| Related Pathway: 86, 110, 132, 149, 170 | |||||||||||||||
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||||||||||||||
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