|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for NO.sGC_5coord | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | sGC_Stone_
Marletta | 15 | Pathway |
sGC | | This features the two step binding of NO to soluble Guanylyl Cyclase as proposed by Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9. There is a fast step binding scheme and a slow step binding scheme. The difference lies in the binding of a NO to a non-heme site on sGC, which may not necessarily be the same site of binding during the initial binding. The rates have been directly used from their models |
NO.sGC_5coord acting as a Molecule in sGC_Stone_Marletta Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | NO.sGC_5coord | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 0 | 0.0016667 | No | | This is the active sGC, a 5-coordinate complex formed after a series of reaction steps, involving the formation of a 6 coordinate complex which converted to a 5-coordinate complex. |
NO.sGC_5coord acting as a Summed Molecule in sGC_Stone_Marletta Network
| Accession Name | Pathway Name | Target | Input | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | sGCtot | NO.sGC_5coord
NO.sGC5accord
| | This is the sumtotal of the sGC activated via two binding mecanisms as reported by Stone and Marletta, 1996, Biochemistry, 35(4):1093-1099. |
NO.sGC_5coord acting as a Product in a reaction in sGC_Stone_Marletta Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | act_sGCfast | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 20
(s^-1) | 0.2
(s^-1) | Keq = 0.01(uM) | 0.05sec | Substrate
NO.SGC_6coord
Product
NO.sGC_5coord
| | Rates used directly from Stone and Marletta,1996,Biochemistry, 35(4):1093-1099. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
