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Molecule Parameter List for NO.sGC_5coord

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

NO.sGC_5coord participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
sGC_Stone_ Marletta	15	Pathway	sGC
This features the two step binding of NO to soluble Guanylyl Cyclase as proposed by Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9. There is a fast step binding scheme and a slow step binding scheme. The difference lies in the binding of a NO to a non-heme site on sGC, which may not necessarily be the same site of binding during the initial binding. The rates have been directly used from their models

NO.sGC_5coord acting as a Molecule in  sGC_Stone_Marletta Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
NO.sGC_5coord	sGC_Stone_ Marletta Accession No. : 15	sGC Pathway No. : 69	0	0.0016667	No
This is the active sGC, a 5-coordinate complex formed after a series of reaction steps, involving the formation of a 6 coordinate complex which converted to a 5-coordinate complex.

NO.sGC_5coord acting as a Summed Molecule in  sGC_Stone_Marletta Network

Accession Name	Pathway Name	Target	Input
sGC_Stone_ Marletta Accession No. : 15	sGC Pathway No. : 69	sGCtot	NO.sGC_5coord NO.sGC5accord
This is the sumtotal of the sGC activated via two binding mecanisms as reported by Stone and Marletta, 1996, Biochemistry, 35(4):1093-1099.

NO.sGC_5coord acting as a Product in a reaction in  sGC_Stone_Marletta Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
act_sGCfast	sGC_Stone_ Marletta Accession No. : 15	sGC Pathway No. : 69	20 (s^-1)	0.2 (s^-1)	Keq = 0.01(uM)	0.05sec	Substrate NO.SGC_6coord Product NO.sGC_5coord
Rates used directly from Stone and Marletta,1996,Biochemistry, 35(4):1093-1099.