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Molecule Parameter List for cGMP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | Kuroda_GC | 18 | Pathway |
SGC | | This model of sGC is based on the paper by Kuroda S. et al. J Neurosci. (2001) 21(15):5693-702. This models features the activation of sGC by NO, synthesis of cGMP, activity of PKG and PP2A in the synapse. The rates and concentrations have been taken from published literature. |
cGMP acting as a Molecule in Kuroda_GC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | cGMP | Kuroda_GC
Accession No. : 18 | SGC
Pathway No. : 88 | 0 | 0.0016667 | No | | |
cGMP acting as a Substrate for an Enzyme in Kuroda_GC Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PDE /
kenz | Kuroda_GC
Accession No. : 18 | SGC
Pathway No. : 88 | 2 | 3.87 | 4 | explicit E-S complex | Substrate
cGMP
Product
5prime_GMP
| | Km - 2 Vmax - 3.87 Thru personal Correspondence with Shinya Kuroda... rates initially from Turko et al., 1998, Biochem J, 329, 505-510 .. |
cGMP acting as a Product of an Enzyme in Kuroda_GC Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | NO_GC /
kenz | Kuroda_GC
Accession No. : 18 | SGC
Pathway No. : 88 | 44.9998 | 7.35 | 4 | explicit E-S complex | Substrate
GTP
Product
cGMP
| | Km - 45 Vamx - 7.35 Shinya Kuroda, J.Neurosci, 2001, 21(15):5693-5702. |
cGMP acting as a Substrate in a reaction in Kuroda_GC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | cGMPbindPKG | Kuroda_GC
Accession No. : 18 | SGC
Pathway No. : 88 | 10
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.05(uM) | - | Substrate
PKG
cGMP
Product
cGMP.PKG
| | Kd - 0.05uM Shinya Kuroda, 2001, J.Neurosci., 21(15):5693-5702. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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