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Molecule Parameter List for cGMP.PKG | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| cGMP.PKG participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| Kuroda_GC | 18 | Pathway | SGC |
| This model of sGC is based on the paper by Kuroda S. et al. J Neurosci. (2001) 21(15):5693-702. This models features the activation of sGC by NO, synthesis of cGMP, activity of PKG and PP2A in the synapse. The rates and concentrations have been taken from published literature. | |||
cGMP.PKG acting as a Molecule in Kuroda_GC Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| cGMP.PKG | Kuroda_GC Accession No. : 18 | SGC Pathway No. : 88 | 0 | 0.0016667 | No | |
cGMP.PKG acting as an Enzyme in Kuroda_GC Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| cGMP.PKG / kenz | Kuroda_GC Accession No. : 18 | SGC Pathway No. : 88 | 0.2 | 0.72 | 4 | explicit E-S complex | Substrate Gsub Product Gsub* |
| Km - 0.2 Vmax - 0.72 Shinya Kuroda, J.Neurosci, 2001, 21(15):5693-5702 | |||||||
cGMP.PKG acting as a Product in a reaction in Kuroda_GC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| cGMPbindPKG | Kuroda_GC Accession No. : 18 | SGC Pathway No. : 88 | 10 (uM^-1 s^-1) | 0.5 (s^-1) | Kd(bf) = 0.05(uM) | - | Substrate PKG cGMP Product cGMP.PKG |
| Kd - 0.05uM Shinya Kuroda, 2001, J.Neurosci., 21(15):5693-5702. | |||||||