| Name | CondorelliGC |
| Accession Type | Pathway |
| Transcriber | Sudhir Sivakumaran, NCBS |
| Developer | Condorelli P and George SC. |
| Entry Date (YYYY-MM-DD) | 2001-12-25 00:00:00 |
| Species | Generic mammalian |
| Tissue | Pulmonary and vascular smooth muscle |
| Cell Compartment | Cytosol |
| Source | Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9). ( peer-reviewed publication |
| Methodology | Quantitative match to experiments |
| Model Implementation | Mathematically equivalent |
| Model Validation | Approximates orginal data, Quantitatively predicts new data |
| Notes | This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than previously reported. |
