| Name | NonOsc_Ca_IP3metabolism |
| Accession Type | Network |
| Transcriber | Jyoti Mishra, NCBS |
| Developer | Jyoti Mishra, NCBS |
| Entry Date (YYYY-MM-DD) | 2002-04-03 00:00:00 |
| Species | Generic mammalian |
| Tissue | Brain - Neuronal |
| Cell Compartment | Cytosol |
| Source | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) |
| Methodology | Quantitative match to experiments, Qualitative |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Approximates original data |
| Notes | This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
