 |  CDK2-CyclinA_
activation_
pathway |
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Accession information for CDK2-CyclinA_activation_pathway (Accession Number 42)
Reaction Scheme
Accession Basic Parameters
| Name | CDK2-CyclinA_activation_pathway |
| Accession Type | Pathway |
| Transcriber | Sharat J. Vayttaden, NCBS |
| Developer | May C. Morris, Claire Gondeau, John A. Tainer, and Gilles Divita |
| Entry Date (YYYY-MM-DD) | 2003-01-11 00:00:00 |
| Species | Human, Xenopus |
| Tissue | Expressed in E.coli |
| Cell Compartment | Cytosol |
| Source | Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53. ( peer-reviewed publication ) |
| Methodology | Qualitative |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Approximates original data |
| Notes | In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53. |
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