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Molecule Parameter List for R

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
R participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    no_fb
    		• 44Pathway
    MAPK_Asthagiri_no_fb 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines.
    This model simulates the results as per the figure 4 of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    R acting as a Molecule in      MAPK_Asthagiri_no_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    R
  • MAPK_Asthagiri_
    no_fb
    Accession No. : 44
  • MAPK_Asthagiri_
    no_fb
    Pathway No. : 192
    		• 0.4274390No
    R nInit = 10^5 no./cell from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    R acting as a Substrate in a reaction in      MAPK_Asthagiri_no_fb Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    L-bind-R
  • MAPK_Asthagiri_
    no_fb
    Accession No. : 44
  • MAPK_Asthagiri_
    no_fb
    Pathway No. : 192
    		• 0.1666
    (uM^-1 s^-1)    		0.005
    (s^-1)    		Kd(bf) = 0.03(uM)-Substrate
    L
    R

    Product
    C
    Kf = 10^7/M-1 min-1 and Kr is 0.3 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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