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Molecule Parameter List for A2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
A2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    no_fb
    		• 44Pathway
    MAPK_Asthagiri_no_fb 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines.
    This model simulates the results as per the figure 4 of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    A2 acting as a Molecule in      MAPK_Asthagiri_no_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    A2
  • MAPK_Asthagiri_
    no_fb
    Accession No. : 44
  • MAPK_Asthagiri_
    no_fb
    Pathway No. : 192
    		• 0.0427390No
    Second adaptor protein. Tot.no. 10^4 no./cell from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    A2 acting as a Substrate in a reaction in      MAPK_Asthagiri_no_fb Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1C*A1-bind-A2
  • MAPK_Asthagiri_
    no_fb
    Accession No. : 44
  • MAPK_Asthagiri_
    no_fb
    Pathway No. : 192
    		• 5.0001
    (uM^-1 s^-1)    		0.5
    (s^-1)    		Kd(bf) = 0.1(uM)-Substrate
    A2
    C*A1

    Product
    E0*
      kf2 and kr2 are 3*10^8 M-1 min-1 and 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
    2A1-bind-A2
  • MAPK_Asthagiri_
    no_fb
    Accession No. : 44
  • MAPK_Asthagiri_
    no_fb
    Pathway No. : 192
    		• 5.0001
    (uM^-1 s^-1)    		0.5
    (s^-1)    		Kd(bf) = 0.1(uM)-Substrate
    A1
    A2

    Product
    A1A2
      Kc12 and Kd12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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