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Molecule Parameter List for PKC-DAG-AA | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | PKC_2003 | 48 | Pathway |
PKC_2003, PKC | | This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here. |
PKC-DAG-AA acting as a Molecule in PKC_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PKC-DAG-AA | PKC_2003
Accession No. : 48 | PKC
Pathway No. : 200 | 0 | 1000 | No | | |
PKC-DAG-AA acting as a Substrate in a reaction in PKC_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | PKC-act-by-DAG-A
A | PKC_2003
Accession No. : 48 | PKC
Pathway No. : 200 | 2
(s^-1) | 0.2
(s^-1) | Keq = 0.1(uM) | 0.455sec | Substrate
PKC-DAG-AA
Product
PKC-DAG-AA*
| | Assume slowish too. Schaechter and Benowitz |
PKC-DAG-AA acting as a Product in a reaction in PKC_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | PKC-n-DAG-AA | PKC_2003
Accession No. : 48 | PKC
Pathway No. : 200 | 0.018
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 111.1111(uM) | - | Substrate
AA
PKC-DAG
Product
PKC-DAG-AA
| | Reduced kf to 0.66X to match Shinomura et al data. Initial: kf = 3.3333e-9 New: 2e-9 Newer: 2e-8 kb was 0.2 now 2. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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