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Molecule Parameter List for inact-GEF* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| inact-GEF* participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| EGFR_MAPK | 58 | Network | Shared_Object_EGFR_MAPK, MAPK, Ras, EGFR, Sos |
| Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53. | |||
inact-GEF* acting as a Molecule in EGFR_MAPK Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| inact-GEF* | EGFR_MAPK Accession No. : 58 | Ras Pathway No. : 231 | 0 | 1000 | No | |
| Phosphorylation-inactivated form of GEF. See Hordijk et al JBC 269:5 3534-3538 1994 and Buregering et al EMBO J 12:11 4211-4220 1993 | ||||||
inact-GEF* acting as a Product of an Enzyme in EGFR_MAPK Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PKA-active / PKA-phosph-GEF | EGFR_MAPK Accession No. : 58 | EGFR_MAPK Pathway No. : 229 | 7.5 | 9 | 4 | explicit E-S complex | Substrate inact-GEF Product inact-GEF* |
| This pathway inhibits Ras when cAMP is elevated. See: Hordijk et al JBC 269:5 3534-3538 1994 Burgering et al EMBO J 12:11 4211-4220 1993 The rates are the same as used in PKA-phosph-I1 | |||||||
inact-GEF* acting as a Substrate in a reaction in EGFR_MAPK Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
EF* | EGFR_MAPK Accession No. : 58 | Ras Pathway No. : 231 | 1 (s^-1) | 0 (s^-1) | - | - | Substrate inact-GEF* Product inact-GEF |