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Molecule Parameter List for CaM-GEF | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CaM-GEF participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| EGFR_MAPK | 58 | Network | Shared_Object_EGFR_MAPK, MAPK, Ras, EGFR, Sos |
| Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53. | |||
CaM-GEF acting as a Molecule in EGFR_MAPK Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| CaM-GEF | EGFR_MAPK Accession No. : 58 | Ras Pathway No. : 231 | 0 | 1000 | No | |
| See Farnsworth et al Nature 376 524-527 1995 | ||||||
CaM-GEF acting as an Enzyme in EGFR_MAPK Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| CaM-GEF / CaM-GEF-act-ras | EGFR_MAPK Accession No. : 58 | Ras Pathway No. : 231 | 0.505051 | 0.02 | 4 | explicit E-S complex | Substrate GDP-Ras Product GTP-Ras |
| Kinetics same as GEF-bg_act-ras | |||||||
CaM-GEF acting as a Product in a reaction in EGFR_MAPK Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| CaM-bind-GEF | EGFR_MAPK Accession No. : 58 | Ras Pathway No. : 231 | 60 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate CaM-Ca4 inact-GEF Product CaM-GEF |
| We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | |||||||