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Molecule Parameter List for CaM-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaM-GEF* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_MAPK	58	Network	Shared_Object_EGFR_MAPK, MAPK, Ras, EGFR, Sos
Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53.

CaM-GEF acting as a Molecule in EGFR_MAPK Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM-GEF	EGFR_MAPK Accession No. : 58	Ras Pathway No. : 231	0	1000	No
See Farnsworth et al Nature 376 524-527 1995

CaM-GEF acting as an Enzyme in EGFR_MAPK Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CaM-GEF / CaM-GEF-act-ras	EGFR_MAPK Accession No. : 58	Ras Pathway No. : 231	0.505051	0.02	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
Kinetics same as GEF-bg_act-ras

CaM-GEF acting as a Product in a reaction in EGFR_MAPK Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaM-bind-GEF	EGFR_MAPK Accession No. : 58	Ras Pathway No. : 231	60 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.0167(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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