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Molecule Parameter List for PP1-I1*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

PP1-I1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	2	0	0	4	0	0	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_noPKA_ model3	62	Network	Shared_Object_CaMKII_noPKA_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD
This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.

PP1-I1* acting as a Molecule in CaMKII_noPKA_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1-I1*	CaMKII_noPKA_ model3 Accession No. : 62	PP1 Pathway No. : 260	0	0.09	No

PP1-I1*	CaMKII_noPKA_ model3 Accession No. : 62	PP1_PSD Pathway No. : 262	0	0.01	No

PP1-I1* acting as a Substrate for an Enzyme in CaMKII_noPKA_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A-dephosph-PP 1-I*	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
2	PP2A / PP2A-dephosph-PP 1-I*_ PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	15.9999	2	4.1667	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	k1 changed from 3.3e-6 to 6.6e-6
3	CaM_Ca_n-CaNAB / dephosph-PP1-I*	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	4.97079	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
4	CaM_Ca_n-CaNAB / dephosph-PP1-I*_ PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	4.97071	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1

PP1-I1* acting as a Product in a reaction in CaMKII_noPKA_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Inact-PP1	CaMKII_noPKA_ model3 Accession No. : 62	PP1 Pathway No. : 260	499.981 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0002(uM)	-	Substrate I1* PP1-active Product PP1-I1*
	K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
2	Inact-PP1	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	499.98 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0002(uM)	-	Substrate I1* PP1-active_PSD Product PP1-I1*
	K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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