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Molecule Parameter List for RCC1-GDP.Ran

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
RCC1-GDP.Ran participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
RanGTPase70Network
Shared_Object_RanGTPase,  Nucleus,  Cytoplasm 
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

RCC1-GDP.Ran acting as a Molecule in  RanGTPase Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
RCC1-GDP.RanRanGTPase
Accession No. : 70		Nucleus
Pathway No. : 305		012000No
RCC1-GDP.Ran Ran-GDP complex bound to RCC1 Catherine Chaillan-Huntington et al (2000) J.Biol.Chem. 275(8):5874-5879. Nuclear volume = 1.2pL = 1.2e-15 m^3 Gorlich D et al (2003) EMBO J 22(5):1088-1100

RCC1-GDP.Ran acting as a Substrate in a reaction in  RanGTPase Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • GDP_
    dissociation
    		• RanGTPase
    Accession No. : 70    		Nucleus
    Pathway No. : 305    		21
    (s^-1)    		11
    (uM^-1 s^-1)    		Kd(cb) = 0.5238(uM)-Substrate
    RCC1-GDP.Ran

    Product
    GDP
    RCC1-Ran
    Release of GDP from the GDP-Ran complex with RCC1 Kf = 21 /sec Kb = 1.1e+07 /M/sec = 1.1e+01 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100

    RCC1-GDP.Ran acting as a Product in a reaction in      RanGTPase Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    RCC1_bindingRanGTPase
    Accession No. : 70    		Nucleus
    Pathway No. : 305    		74.0006
    (uM^-1 s^-1)    		55
    (s^-1)    		Kd(bf) = 0.7432(uM)-Substrate
    GDP.Ran-nuclear
    RCC1

    Product
    RCC1-GDP.Ran
    Binding of GDP-Ran complex with RCC1 Kf = 7.4e+07 /M/sec = 7.4e+01 /uM/sec Kb = 55 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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