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Molecule Parameter List for GTP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GTP participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| RanGTPase | 70 | Network | Shared_Object_RanGTPase, Nucleus, Cytoplasm |
| This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs. | |||
GTP acting as a Molecule in RanGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| GTP | RanGTPase Accession No. : 70 | Nucleus Pathway No. : 305 | 500.007 | 12000 | No | |
| GTP Initial GTP concentration = 500uM Nuclear volume = 1.2 pL = 1.2e-15 m^3 Table II footnote Gorlich D et al (2003) EMBO J 22(5):1088-1100 | ||||||
GTP acting as a Substrate in a reaction in RanGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| GTP_binding | RanGTPase Accession No. : 70 | Nucleus Pathway No. : 305 | 0.6 (uM^-1 s^-1) | 19 (s^-1) | Kd(bf) = 31.6669(uM) | - | Substrate GTP RCC1-Ran Product RCC1-RanGTP |
| Binding of GTP to GDP free Ran-RCC1 complex Kf = 0.6e+06 /M/sec = 0.6 /uM/sec Kb = 19 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100 | |||||||