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Molecule Parameter List for GTP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
GTP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
RanGTPase70Network
Shared_Object_RanGTPase Nucleus Cytoplasm 
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

GTP acting as a Molecule in  
RanGTPase Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
GTPRanGTPase
Accession No. : 70
Nucleus
Pathway No. : 305
500.00712000No
GTP Initial GTP concentration = 500uM Nuclear volume = 1.2 pL = 1.2e-15 m^3 Table II footnote Gorlich D et al (2003) EMBO J 22(5):1088-1100

GTP acting as a Substrate in a reaction in  
RanGTPase Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
GTP_bindingRanGTPase
Accession No. : 70
Nucleus
Pathway No. : 305
0.6
(uM^-1 s^-1)
19
(s^-1)
Kd(bf) = 31.6669(uM)-Substrate
GTP
RCC1-Ran

Product
RCC1-RanGTP
Binding of GTP to GDP free Ran-RCC1 complex Kf = 0.6e+06 /M/sec = 0.6 /uM/sec Kb = 19 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100



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