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Molecule Parameter List for PKC-Ca-DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-Ca-DAG participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_PKM
    		• 80Network
    Shared_Object_Ajay_Bhalla_2007_PKM,  PKC,  MAPK,  
    Ras,  CaM,  PKM 
    This is a non-bistable model of ERKII signaling that also incorporates PKM synthesis triggered by Ca influx. It is a simplified variant of the model of Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80.

    PKC-Ca-DAG acting as a Molecule in      Ajay_Bhalla_2007_PKM Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PKC-Ca-DAG
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• PKC
    Pathway No. : 370    		01.5No

    PKC-Ca-DAG acting as a Substrate in a reaction in      Ajay_Bhalla_2007_PKM Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PKC-DAG-to-memb
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• PKC
    Pathway No. : 370    		1
    (s^-1)    		0.1
    (s^-1)    		Keq = 0.1(uM)0.909secSubstrate
    PKC-Ca-DAG

    Product
    PKC-DAG-memb*
    Raise kb from .087 to 0.1 to match data from Shinomura et al. Lower kf from 1.155 to 1.0 to match data from Shinomura et al.

    PKC-Ca-DAG acting as a Product in a reaction in      Ajay_Bhalla_2007_PKM Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_PKM
    Accession No. : 80
    		• PKC
    Pathway No. : 370    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.377(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
    Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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