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Molecule Parameter List for PI3K

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PI3K* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
BDNF_Receptor	86	Network	Shared_Object_BDNF_Receptor, TrKB_mod, PI3K_mod
BDNF recetor signaling is one of the sub-model in BDNF signaling cascade. BDNF activates TrKB, leading to the stimulation of PI3K and formation of PIP3.

PI3K acting as a Molecule in BDNF_Receptor Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PI3K	BDNF_Receptor Accession No. : 86	PI3K_mod Pathway No. : 1084	0.1	999.97	No

PI3K acting as a Substrate in a reaction in BDNF_Receptor Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PI3K_act	BDNF_Receptor Accession No. : 86	PI3K_mod Pathway No. : 1084	5.0002 (uM^-1 s^-1)	0.08 (s^-1)	Kd(bf) = 0.016(uM)	-	Substrate PI3K Shc_Grb2-Gab1_ clx Product* Shc*_Grb2-Gab1_ PI3K_clx
2	basal_PI3K_act	BDNF_Receptor Accession No. : 86	PI3K_mod Pathway No. : 1084	0.0007 (s^-1)	0.45 (s^-1)	Keq = 661.7647(uM)	2.219sec	Substrate PI3K Product PI3K_basal
3	PI3K_bind_ Ras-GTP	BDNF_Receptor Accession No. : 86	Shared_Object_ BDNF_Receptor Pathway No. : 1082	0 (s^-1)	5 (s^-1)	Keq = 1666666.6667(uM)	-	Substrate PI3K Product Ras-GTP_PI3K

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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