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Molecule Parameter List for Shc

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Shc participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
BDNF_Receptor	86	Network	Shared_Object_BDNF_Receptor,  TrKB_mod,  PI3K_mod
BDNF recetor signaling is one of the sub-model in BDNF signaling cascade. BDNF activates TrKB, leading to the stimulation of PI3K and formation of PIP3.

Shc acting as a Molecule in  BDNF_Receptor Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Shc	BDNF_Receptor Accession No. : 86	PI3K_mod Pathway No. : 1084	0.5	999.97	No

Shc acting as a Substrate for an Enzyme in  BDNF_Receptor Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
BDNF_TrkB2*_clx  / Shc_phospho	BDNF_Receptor Accession No. : 86	TrKB_mod Pathway No. : 1083	0.833306	0.3	4	explicit E-S complex	Substrate Shc Product Shc*

Shc acting as a Product in a reaction in  BDNF_Receptor Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Shc*_dephospho	BDNF_Receptor Accession No. : 86	PI3K_mod Pathway No. : 1084	0.2 (s^-1)	0 (s^-1)	-	-	Substrate Shc* Product Shc