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Molecule Parameter List for Shc*_Grb2-Gab1_clx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Shc*_Grb2-Gab1_clx participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
BDNF_Receptor86Network
Shared_Object_BDNF_Receptor,  TrKB_mod,  PI3K_mod 
BDNF recetor signaling is one of the sub-model in BDNF signaling cascade. BDNF activates TrKB, leading to the stimulation of PI3K and formation of PIP3.

Shc*_Grb2-Gab1_clx acting as a Molecule in  BDNF_Receptor Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
Shc*_Grb2-Gab1_clxBDNF_Receptor
Accession No. : 86		PI3K_mod
Pathway No. : 1084		0999.97No

Shc*_Grb2-Gab1_clx acting as a Substrate in a reaction in  BDNF_Receptor Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
PI3K_actBDNF_Receptor
Accession No. : 86		PI3K_mod
Pathway No. : 1084		5.0002
(uM^-1 s^-1)		0.08
(s^-1)		Kd(bf) = 0.016(uM)-Substrate
PI3K
  • Shc*_Grb2-Gab1_
    clx

    Product
  • Shc*_Grb2-Gab1_
    PI3K_clx

    • Shc*_Grb2-Gab1_clx acting as a Product in a reaction in      BDNF_Receptor Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    bind_Gab1BDNF_Receptor
    Accession No. : 86    		PI3K_mod
    Pathway No. : 1084    		0.3
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 3.3333(uM)-Substrate
    Gab1
    Shc*_Grb2_clx

    Product
  • Shc*_Grb2-Gab1_
    clx


    • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.