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Molecule Parameter List for Grb2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| Grb2 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | BDNF_Receptor | 86 | Network |
Shared_Object_BDNF_Receptor, TrKB_mod, PI3K_mod | | BDNF recetor signaling is one of the sub-model in BDNF signaling cascade. BDNF activates TrKB, leading to the stimulation of PI3K and formation of PIP3. |
Grb2 acting as a Molecule in BDNF_Receptor Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Grb2 | BDNF_Receptor
Accession No. : 86 | Shared_Object_
BDNF_Receptor
Pathway No. : 1082 | 1 | 999.97 | No | | There is probably a lot of it in the cell: it is also known as Ash (abundant src homology protein I think). Also Waters et al JBC 271:30 18224 1996 say that only a small fraction of cellular Grb is precipitated out when SoS is precipitated. As most of the Sos seems to be associated with Grb2, it would seem like there is a lot of the latter. Say 1 uM. I haven't been able to find a decent.... |
Grb2 acting as a Substrate in a reaction in BDNF_Receptor Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
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