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Molecule Parameter List for PIP3_AKT | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | AKT | 87 | Network |
Shared_Object_AKT, AKT_mod | | This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR. |
PIP3_AKT acting as a Molecule in AKT Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PIP3_AKT | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 0 | 999.97 | No |
PIP3_AKT acting as a Substrate for an Enzyme in AKT Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PIP3_PDK1 /
phospho_thr308 | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 0.399987 | 10 | 4 | explicit E-S complex | Substrate
PIP3_AKT
Product
PIP3_AKT_thr308
|
PIP3_AKT acting as a Product of an Enzyme in AKT Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PP2A /
Dephosph_
AKTthr308
| AKT
Accession No. : 87 | Shared_Object_
AKT
Pathway No. : 1085 | 4.80015 | 1.8 | 4 | explicit E-S complex | Substrate
PIP3_AKT_thr308
Product
PIP3_AKT
|
PIP3_AKT acting as a Product in a reaction in AKT Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | PIP3_bind_AKT | AKT
Accession No. : 87 | AKT_mod
Pathway No. : 1086 | 45.0003
(uM^-1 s^-1) | 0.089
(s^-1) | Kd(bf) = 0.002(uM) | - | Substrate
AKT
PIP3
Product
PIP3_AKT
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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