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Molecule Parameter List for PKC-DAG-AA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-DAG-AA participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
    		• 9Network
    Shared_Object_MAPK_MKP1_oscillation,  PKC,  MAPK,  
    PLA2,  Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    PKC-DAG-AA acting as a Molecule in      MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PKC-DAG-AA
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PKC
    Pathway No. : 60    		01000No

    PKC-DAG-AA acting as a Substrate in a reaction in      MAPK_MKP1_oscillation Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • PKC-act-by-DAG-A
    A
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PKC
    Pathway No. : 60    		2
    (s^-1)    		0.2
    (s^-1)    		Keq = 0.1(uM)0.455secSubstrate
    PKC-DAG-AA

    Product
    PKC-DAG-AA*
    Assume slowish too. Schaechter and Benowitz

    PKC-DAG-AA acting as a Product in a reaction in      MAPK_MKP1_oscillation Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PKC-n-DAG-AA
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PKC
    Pathway No. : 60    		0.018
    (uM^-1 s^-1)    		2
    (s^-1)    		Kd(bf) = 111.1111(uM)-Substrate
    AA
    PKC-DAG

    Product
    PKC-DAG-AA
    Reduced kf to 0.66X to match Shinomura et al data. Initial: kf = 3.3333e-9 New: 2e-9 Newer: 2e-8 kb was 0.2 now 2.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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