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Molecule Parameter List for DAG-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

DAG-Ca-PLA2* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
MAPK_MKP1_ oscillation	9	Network	Shared_Object_MAPK_MKP1_oscillation, PKC, MAPK, PLA2, Ras
This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

DAG-Ca-PLA2* acting as a Molecule in MAPK_MKP1_oscillation Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
DAG-Ca-PLA2*	MAPK_MKP1_ oscillation Accession No. : 9	PLA2 Pathway No. : 62	0	1000	No

DAG-Ca-PLA2* acting as an Enzyme in MAPK_MKP1_oscillation Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
DAG-Ca-PLA2* / kenz	MAPK_MKP1_ oscillation Accession No. : 9	PLA2 Pathway No. : 62	20	60	4	explicit E-S complex	Substrate APC Product AA
10 X raise oct 22 12 X raise oct 24 + conversion to k2 =4 k3*

DAG-Ca-PLA2* acting as a Product in a reaction in MAPK_MKP1_oscillation Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
DAG-Ca-PLA2-act	MAPK_MKP1_ oscillation Accession No. : 9	PLA2 Pathway No. : 62	0.003 (uM^-1 s^-1)	4 (s^-1)	Kd(bf) = 1333.3333(uM)	-	Substrate DAG PLA2-Ca* Product DAG-Ca-PLA2*
27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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