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Molecule Parameter List for CaM_dash_Ca4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CaM_dash_Ca4 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 1 | 2 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| CaMKIV_submodel | 93 | Network | kinetics, compartment_1 |
| Calcium-calmodulin dependent protein kinase IV (CaMKIV) pathway is one of the sub-model in signaling cascade regulating mRNA synthesis | |||
CaM_dash_Ca4 acting as a Molecule in CaMKIV_submodel Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| CaM_dash_Ca4 | CaMKIV_submodel Accession No. : 93 | kinetics Pathway No. : 1110 | 0 | 1000 | No | |
CaM_dash_Ca4 acting as a Product of an Enzyme in CaMKIV_submodel Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PKA_dash_active / CaMKKphosph | CaMKIV_submodel Accession No. : 93 | kinetics Pathway No. : 1110 | 4.6999 | 0.6833 | 3.99997073156 | explicit E-S complex | Substrate CaMKK_CaM_Ca_c Product CaMKKp CaM_dash_Ca4 |
CaM_dash_Ca4 acting as a Substrate in a reaction in CaMKIV_submodel Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | |
| 1 | CaMKIVcomplx | CaMKIV_submodel Accession No. : 93 | kinetics Pathway No. : 1110 | 0.1332 (uM^-1 s^-1) | 0.004 (s^-1) | Kd(bf) = 0.03(uM) | - | Substrate CaMKIVc CaM_dash_Ca4 Product CaMKIV_CaM_Ca_c |
| Kd from PMID: 9705275 | ||||||||
| 2 | CaMKKcomplx | CaMKIV_submodel Accession No. : 93 | kinetics Pathway No. : 1110 | 4.05 (uM^-1 s^-1) | 0.02 (s^-1) | Kd(bf) = 0.0049(uM) | - | Substrate CaMKK_c CaM_dash_Ca4 Product CaMKK_CaM_Ca_c |
| Kd from PMID: 9705275 | ||||||||
CaM_dash_Ca4 acting as a Product in a reaction in CaMKIV_submodel Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
dash_bind_dash_ Ca | CaMKIV_submodel Accession No. : 93 | kinetics Pathway No. : 1110 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM_dash_Ca3 Product CaM_dash_Ca4 |
| Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | |||||||