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Molecule Parameter List for CaM_dash_Ca4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaM_dash_Ca4* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	1	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKIV_submodel	93	Network	kinetics, compartment_1
Calcium-calmodulin dependent protein kinase IV (CaMKIV) pathway is one of the sub-model in signaling cascade regulating mRNA synthesis

CaM_dash_Ca4 acting as a Molecule in CaMKIV_submodel Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM_dash_Ca4	CaMKIV_submodel Accession No. : 93	kinetics Pathway No. : 1110	0	1000	No

CaM_dash_Ca4 acting as a Product of an Enzyme in CaMKIV_submodel Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKA_dash_active / CaMKKphosph	CaMKIV_submodel Accession No. : 93	kinetics Pathway No. : 1110	4.6999	0.6833	3.99997073156	explicit E-S complex	Substrate CaMKK_CaM_Ca_c Product CaMKKp CaM_dash_Ca4

CaM_dash_Ca4 acting as a Substrate in a reaction in CaMKIV_submodel Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKIVcomplx	CaMKIV_submodel Accession No. : 93	kinetics Pathway No. : 1110	0.1332 (uM^-1 s^-1)	0.004 (s^-1)	Kd(bf) = 0.03(uM)	-	Substrate CaMKIVc CaM_dash_Ca4 Product CaMKIV_CaM_Ca_c
	Kd from PMID: 9705275
2	CaMKKcomplx	CaMKIV_submodel Accession No. : 93	kinetics Pathway No. : 1110	4.05 (uM^-1 s^-1)	0.02 (s^-1)	Kd(bf) = 0.0049(uM)	-	Substrate CaMKK_c CaM_dash_Ca4 Product CaMKK_CaM_Ca_c
	Kd from PMID: 9705275

CaM_dash_Ca4 acting as a Product in a reaction in CaMKIV_submodel Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaM_dash_Ca3_ dash_bind_dash_ Ca	CaMKIV_submodel Accession No. : 93	kinetics Pathway No. : 1110	0.465 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 21.5051(uM)	-	Substrate Ca CaM_dash_Ca3 Product CaM_dash_Ca4
Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 6e5 so kf = 7.75e-7, kb = 10*

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