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Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PP2A* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	6	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

PP2A acting as a Molecule in mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP2A	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	0.15	1000	Yes
Concentration from DOQCS accession no. 90

PP2A acting as an Enzyme in mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / dephosp_S6K	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	8.8005	1	4	explicit E-S complex	Substrate active_RSK2 Product ppRSK

2	PP2A / PP2A_dash_ dephosph_dash_ I1	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	7.8283	6	4.16666666667	explicit E-S complex	Substrate I1_star Product I1
	PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
3	PP2A / PP2A_dash_ dephosph_dash_ PP1_dash_I_p	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	7.8283	6	4.16666666667	explicit E-S complex	Substrate PP1_dash_I1_ star Product PP1_dash_I1
	k1 changed from 3.3e-6 to 6.6e-6
4	PP2A / CaMKKdephosph	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	4.9999	0.7	4	explicit E-S complex	Substrate CaMKKp Product CaMKK_c

5	PP2A / CaMKIVdephos	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	8.8002	2	4	explicit E-S complex	Substrate pCaMKIV_CaM_Ca_ c Product CaMKIV_CaM_Ca_c

6	PP2A / dephos_S6K	mRNA synthesis Accession No. : 94	kinetics Pathway No. : 1112	8.8005	1	4	explicit E-S complex	Substrate pRSK Product RSK

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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