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Molecule Parameter List for inact_dash_GEF_star | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | mRNA synthesis | 94 | Network |
kinetics, compartment_1, compartment_2 | | The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway. |
inact_dash_GEF_star acting as a Molecule in mRNA synthesis Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | inact_dash_GEF_star | mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 0 | 1000 | No | | Phosphorylation-inactivated form of GEF. See Hordijk et al JBC 269:5 3534-3538 1994 and Buregering et al EMBO J 12:11 4211-4220 1993 |
inact_dash_GEF_star acting as a Product of an Enzyme in mRNA synthesis Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PKA_dash_active /
PKA_dash_
phosph_dash_GEF
| mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 7.5 | 9 | 4 | explicit E-S complex | Substrate
inact_dash_GEF
Product
inact_dash_GEF_
star
| | This pathway inhibits Ras when cAMP is elevated. See: Hordijk et al JBC 269:5 3534-3538 1994 Burgering et al EMBO J 12:11 4211-4220 1993 The rates are the same as used in PKA-phosph-I1 |
inact_dash_GEF_star acting as a Substrate in a reaction in mRNA synthesis Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | dephosph_dash_
inact_dash_GEF_
star | mRNA synthesis
Accession No. : 94 | kinetics
Pathway No. : 1112 | 1
(s^-1) | 0
(s^-1) | - | - | Substrate
inact_dash_GEF_
star
Product
inact_dash_GEF
| | |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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