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Molecule Parameter List for CaMKK_c | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CaMKK_c participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| mRNA synthesis | 94 | Network | kinetics, compartment_1, compartment_2 |
| The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway. | |||
CaMKK_c acting as a Molecule in mRNA synthesis Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| CaMKK_c | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 0.5 | 1000 | No | |
| Concentration calculated from PMID: 7883770 | ||||||
CaMKK_c acting as a Product of an Enzyme in mRNA synthesis Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PP2A / CaMKKdephosph | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 4.9999 | 0.7 | 4 | explicit E-S complex | Substrate CaMKKp Product CaMKK_c |
CaMKK_c acting as a Substrate in a reaction in mRNA synthesis Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| CaMKKcomplx | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 4.05 (uM^-1 s^-1) | 0.02 (s^-1) | Kd(bf) = 0.0049(uM) | - | Substrate CaMKK_c CaM_dash_Ca4 Product CaMKK_CaM_Ca_c |
| Kd from PMID: 9705275 | |||||||