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Molecule Parameter List for Sos | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sos participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| mRNA synthesis | 94 | Network | kinetics, compartment_1, compartment_2 |
| The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway. | |||
Sos acting as a Molecule in mRNA synthesis Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Sos | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 0.1 | 1000 | No | |
Sos acting as a Substrate for an Enzyme in mRNA synthesis Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| MAPK_star / phosph_Sos | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 2.56 | 10 | 4 | explicit E-S complex | Substrate Sos Product Sos_star |
Sos acting as a Substrate in a reaction in mRNA synthesis Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| Grb2_bind_Sos | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 0.25 (uM^-1 s^-1) | 0.0168 (s^-1) | Kd(bf) = 0.0672(uM) | - | Substrate Grb2 Sos Product Sos.Grb2 |
Sos acting as a Product in a reaction in mRNA synthesis Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| dephosph_Sos | mRNA synthesis Accession No. : 94 | kinetics Pathway No. : 1112 | 0.001 (s^-1) | 0.1 (s^-1) | Keq = 100(uM) | 9.901sec | Substrate Sos_star Product Sos |