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Molecule Parameter List for CREB_CRE

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CREB_CRE participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1003100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
mRNA synthesis94Network
kinetics,  compartment_1,  compartment_2 
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

CREB_CRE acting as a Molecule in  mRNA synthesis Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CREB_CREmRNA synthesis
Accession No. : 94		compartment_1
Pathway No. : 1113		0.5370No
Concentration from PMID: 11483993

CREB_CRE acting as a Substrate for an Enzyme in  mRNA synthesis Network
 Enzyme Molecule /
Enzyme Activity		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1active_RSK2_n  /
RSK_phsoph_CREB		mRNA synthesis
Accession No. : 94		compartment_1
Pathway No. : 1113		50.14explicit E-S complexSubstrate
CREB_CRE

Product
pCREB_CRE
   
2pMSK1_n  /
  • MSK1_dash_
    phospho
    		• mRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		20.14explicit E-S complexSubstrate
    CREB_CRE

    Product
    pCREB_CRE
       
    3
  • pCaMKIV_CaM_Ca_
    nuc      /
    CREB_phosph
    		• mRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		5.50.74explicit E-S complexSubstrate
    CREB_CRE

    Product
    pCREB_CRE
       

    CREB_CRE acting as a Product of an Enzyme in      mRNA synthesis Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1_active_n  /
    CREBdephos    		mRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		514explicit E-S complexSubstrate
    pCREB_CRE

    Product
    CREB_CRE


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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