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Molecule Parameter List for pCREB_CRE

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*pCREB_CRE* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	3	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
mRNA synthesis	94	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

pCREB_CRE acting as a Molecule in mRNA synthesis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
pCREB_CRE	mRNA synthesis Accession No. : 94	compartment_1 Pathway No. : 1113	0	370	No

pCREB_CRE acting as a Substrate for an Enzyme in mRNA synthesis Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1_active_n / CREBdephos	mRNA synthesis Accession No. : 94	compartment_1 Pathway No. : 1113	5	1	4	explicit E-S complex	Substrate pCREB_CRE Product CREB_CRE

pCREB_CRE acting as a Product of an Enzyme in mRNA synthesis Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	active_RSK2_n / RSK_phsoph_CREB	mRNA synthesis Accession No. : 94	compartment_1 Pathway No. : 1113	5	0.1	4	explicit E-S complex	Substrate CREB_CRE Product pCREB_CRE

2	pMSK1_n / MSK1_dash_ phospho	mRNA synthesis Accession No. : 94	compartment_1 Pathway No. : 1113	2	0.1	4	explicit E-S complex	Substrate CREB_CRE Product pCREB_CRE

3	pCaMKIV_CaM_Ca_ nuc / CREB_phosph	mRNA synthesis Accession No. : 94	compartment_1 Pathway No. : 1113	5.5	0.7	4	explicit E-S complex	Substrate CREB_CRE Product pCREB_CRE

pCREB_CRE acting as a Substrate in a reaction in mRNA synthesis Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CBP_binds_pCREB	mRNA synthesis Accession No. : 94	compartment_1 Pathway No. : 1113	0.114 (uM^-1 s^-1)	0.025 (s^-1)	Kd(bf) = 0.2193(uM)	-	Substrate CBP pCREB_CRE Product CBP_pCREB_CRE

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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