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Molecule Parameter List for I1n

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
I1n participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001111

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
mRNA synthesis94Network
kinetics,  compartment_1,  compartment_2 
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

I1n acting as a Molecule in  mRNA synthesis Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
I1nmRNA synthesis
Accession No. : 94		compartment_1
Pathway No. : 1113		0370No

I1n acting as a Substrate for an Enzyme in  mRNA synthesis Network
Enzyme Molecule /
Enzyme Activity		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
  • PKA_dash_
    active_n      /
    I1_phospho
    		• mRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		7.594explicit E-S complexSubstrate
    I1n

    Product
    I1_star_n

    I1n acting as a Product of an Enzyme in      mRNA synthesis Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP2An  /
    I1_star_dephosp    		mRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		7.828564explicit E-S complexSubstrate
    I1_star_n

    Product
    I1n

    I1n acting as a Substrate in a reaction in      mRNA synthesis Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Inact_PP1_nmRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		0.5
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.2(uM)-Substrate
    I1n
    PP1_active_n

    Product
    PP1_dash_I1n

    I1n acting as a Product in a reaction in      mRNA synthesis Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PP1_dissocmRNA synthesis
    Accession No. : 94    		compartment_1
    Pathway No. : 1113    		1
    (s^-1)    		0
    (uM^-1 s^-1)    		--Substrate
    PP1_dash_I1n

    Product
    I1n
    PP1_active_n


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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