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Name Notes Model

Molecule Parameter List for inact_dash_GEF_star

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

inact_dash_GEF_star participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics,  compartment_1,  compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

inact_dash_GEF_star acting as a Molecule in  Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
inact_dash_GEF_star	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0	1000	No
Phosphorylation-inactivated form of GEF. See Hordijk et al JBC 269:5 3534-3538 1994 and Buregering et al EMBO J 12:11 4211-4220 1993

inact_dash_GEF_star acting as a Product of an Enzyme in  Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKA_dash_active  / PKA_dash_ phosph_dash_GEF	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	7.5	9	4	explicit E-S complex	Substrate inact_dash_GEF Product inact_dash_GEF_ star
This pathway inhibits Ras when cAMP is elevated. See: Hordijk et al JBC 269:5 3534-3538 1994 Burgering et al EMBO J 12:11 4211-4220 1993 The rates are the same as used in PKA-phosph-I1

inact_dash_GEF_star acting as a Substrate in a reaction in  Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dephosph_dash_ inact_dash_GEF_ star	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	1 (s^-1)	0 (s^-1)	-	-	Substrate inact_dash_GEF_ star Product inact_dash_GEF