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Molecule Parameter List for TrKB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
TrKB participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Differential syn
    thesis of mRNA
    		• 95Network
    kinetics,  compartment_1,  compartment_2 
    The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

    TrKB acting as a Molecule in      Differential synthesis of mRNA Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    TrKB
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		0.251000No

    TrKB acting as a Substrate in a reaction in      Differential synthesis of mRNA Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Dimeriz_TrKB
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		1
    (uM^-1 s^-1)    		0.02
    (s^-1)    		Kd(bf) = 0.02(uM)-Substrate
    BDNF_TrkB_clx
    TrKB

    Product
    BDNF_TrkB2_clx
     
    2Ligand_binding
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		1.0001
    (uM^-1 s^-1)    		0.05
    (s^-1)    		Kd(bf) = 0.05(uM)-Substrate
    BDNF
    TrKB

    Product
    BDNF_TrkB_clx
     

    TrKB acting as a Product in a reaction in      Differential synthesis of mRNA Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    LR_cycling
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
  • Int_BDNF_TrKB2_
    star_clx

    Product
    TrKB


    • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.