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Molecule Parameter List for Sos

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Sos participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Differential syn
    thesis of mRNA
    		• 95Network
    kinetics,  compartment_1,  compartment_2 
    The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

    Sos acting as a Molecule in      Differential synthesis of mRNA Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    Sos
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		0.11000No

    Sos acting as a Substrate for an Enzyme in      Differential synthesis of mRNA Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MAPK_star  /
    phosph_Sos
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		2.56104explicit E-S complexSubstrate
    Sos

    Product
    Sos_star

    Sos acting as a Substrate in a reaction in      Differential synthesis of mRNA Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Grb2_bind_Sos
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		0.25
    (uM^-1 s^-1)    		0.0168
    (s^-1)    		Kd(bf) = 0.0672(uM)-Substrate
    Grb2
    Sos

    Product
    Sos.Grb2

    Sos acting as a Product in a reaction in      Differential synthesis of mRNA Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    dephosph_Sos
  • Differential syn
    thesis of mRNA
    Accession No. : 95
    		• kinetics
    Pathway No. : 1115    		0.001
    (s^-1)    		0.1
    (s^-1)    		Keq = 100(uM)9.901secSubstrate
    Sos_star

    Product
    Sos


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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