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Name Notes Model

Molecule Parameter List for TORC1c

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

TORC1c participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics,  compartment_1,  compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

TORC1c acting as a Molecule in  Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
TORC1c	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.1	1000	No

TORC1c acting as a Substrate for an Enzyme in  Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
SIK2  / TORC1_phso_enz	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	4	0.4	4	explicit E-S complex	Substrate TORC1c Product pTORC1

TORC1c acting as a Product of an Enzyme in  Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CaM_Ca_n_dash_ CaNAB  / CaN_dephos_ TORC1	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.4	0.1	4	explicit E-S complex	Substrate pTORC1 Product TORC1c

TORC1c acting as a Substrate in a reaction in  Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
TORC1_import	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.01 (s^-1)	0.0004 (s^-1)	Keq = 0.037(uM)	96.154sec	Substrate TORC1c Product TORC1c

TORC1c acting as a Product in a reaction in  Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
TORC1_import	Differential syn thesis of mRNA Accession No. : 95	kinetics Pathway No. : 1115	0.01 (s^-1)	0.0004 (s^-1)	Keq = 0.037(uM)	96.154sec	Substrate TORC1c Product TORC1c