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Molecule Parameter List for TORC1n

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*TORC1n* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

TORC1n acting as a Molecule in Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
TORC1n	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	0	370	No

TORC1n acting as a Substrate in a reaction in Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	TORC1_bind_CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CBP_pCREB_CRE TORC1n Product Transcription_ clx

2	TORC1_bind_ CREB_C	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CBP_pCREB_ CaMKIV TORC1n Product Transcription_ Clx_C

3	TORC1_bind_ PP1CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CBP_pCREB_PP1 TORC1n Product Transcr_clx_PP1

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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