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Molecule Parameter List for CREB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CREB* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics, compartment_1, compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

CREB acting as a Molecule in Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	0.5	370	No

CREB acting as a Substrate in a reaction in Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Astar_binds_ CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate A_star CREB Product PP1star_CREB

2	Bstar_bind_CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate B_star CREB Product MAPKstar_CREB

3	Cstar_bind_CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CREB C_star Product CaMKIVstar_CREB

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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