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Name Notes Model

Molecule Parameter List for Transcr_clx_PP1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Transcr_clx_PP1 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Differential syn thesis of mRNA	95	Network	kinetics,  compartment_1,  compartment_2
The model consists of three major pathways: Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1). Each of these converged on CREB activation. We also modeled further interactions with Transducer of regulated CREB activity 1 (TORC1) and the protein kinase A (PKA) pathway.

Transcr_clx_PP1 acting as a Molecule in  Differential synthesis of mRNA Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Transcr_clx_PP1	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	0	370	No

Transcr_clx_PP1 acting as an Enzyme in  Differential synthesis of mRNA Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
Transcr_clx_PP1 / mRNA_PP1	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1.08	0.05	4	explicit E-S complex	Substrate Nucleotides Product PP1mRNA_clx

Transcr_clx_PP1 acting as a Product in a reaction in  Differential synthesis of mRNA Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
TORC1_bind_ PP1CREB	Differential syn thesis of mRNA Accession No. : 95	compartment_1 Pathway No. : 1116	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CBP_pCREB_PP1 TORC1n Product Transcr_clx_PP1