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Molecule List for pathway Gs (Pathway Number 137) in Accession cAMP_pathway (Accession Number 25) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
  arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| |
Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | L | Network | 0 | 0 | Yes | - | | | This ligand could be any of several which bind to the beta adrenergic receptor and other G-protein coupled receptors which activate AC. For the sake of argument, call it isoproterenol. | | 2 | R | Network | 0.0833 | 0 | No | - | | | A typical number of receptors per cell is about 50000. | | 3 | L.R | Network | 0 | 0 | No | - | | | Ligand.Receptor complex | | 4 | GDP.Gabc | Network | 1 | 0 | No | - | | | The resting state of Gs: GDP bound to trimer. From Pang and Sternweis JBC 265:30 18707-12 1990 we get conc est 1.6 uM to 0.8 uM. We'll use 1 uM. | | 5 | L.R.GDP.Gabc | Network | 0 | 0 | No | - | | | This is the ternary complex, where all the action happens. There are actually a lot more steps here, including a final step where the GTP binds the L.R.Ga complex and causes the release of GTP.Ga from the L.R. For simplicity this is excluded. | | 6 | GDP.Ga | Network | 0 | 0 | No | - | | | The inactive GDP-bound form of Gs alpha. | | 7 | Gbg | Network | 0 | 0 | No | - | | | The Gbetagamma dimer. | | 8 | R.GDP.Gabc | Network | 0 | 0 | No | - | | | Fraction of R.GDP.Gabc is about 50% of total R, from Fay et al. Biochemistry 30:5066-5075(1991) Since this is not the same receptor, this value is a bit uncertain. |
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