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Enzyme List for pathway PLC_g (Pathway Number 321) in Accession Ajay_Bhalla_2004_PKM_Tuning (Accession Number 76) |
Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.Further ordering can be done according to header.   arrow indicates that ordering is done according to ascending or descending order. |
| Enzyme Molecule / Enzyme Activity | Pathway Name / Pathway No. | Km (uM) | kcat (s^-1) | Ratio (k2/k3) | Enzyme Type | Reagents | ||
| 1 | Ca.PLC_g / PIP2_hydrolysis | PLC_g Pathway No. 321 | 97.2222 | 14 | 4 | explicit E-S complex | Substrate: PIP2 Product : DAG IP3 | |
| Mainly Homma et al JBC 263:14 1988 pp 6592, but these parms are the Ca-stimulated form. It is not clear whether the enzyme is activated by tyrosine phosphorylation at this point or not. Wahl et al JBC 267:15 10447-10456 1992 say that the Ca_stim and phosph form has 7X higher affinity for substrate than control. This is close to Wahl's figure 7, which I am using as reference. | ||||||||
| 2 | Ca.PLC_g* / PIP2_hydrolysis | PLC_g Pathway No. 321 | 19.7917 | 57 | 4 | explicit E-S complex | Substrate: PIP2 Product : DAG IP3 | |
| Mainly Homma et al JBC 263:14 1988 pp 6592, but these parms are the Ca-stimulated form. It is not clear whether the enzyme is activated by tyrosine phosphorylation at this point or not. Wahl et al JBC 267:15 10447-10456 1992 say that this has 7X higher affinity for substrate than control. | ||||||||