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Reaction List for pathway PP2B (Pathway Number 342) in Accession Ajay_Bhalla_2004_PKM_MKP3_Tuning (Accession Number 77) |
Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.   indicates that ordering is done according to ascending or descending order.Keq is calculated only for first order reactions. Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules] |
| Reaction Name | Pathway Name / Pathway No. | Kf | Kb | Kd | tau | Reagents | |
| 1 | Ca-bind-CaNAB | PP2B Pathway No. 342 | 10008.4 (uM^-2 s^-1) | 1 (s^-1) | Kd(af) = 0.01(uM) | - | Substrate: CaNAB Ca Ca Products: CaNAB-Ca2 | going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1 |
| 2 | B | PP2B Pathway No. 342 | 600.003 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.0017(uM) | - | Substrate: CaM-Ca4 CaNAB-Ca4 Products: CaMCa4-CaNAB |
| 3 | 2 | PP2B Pathway No. 342 | 3.6 (uM^-2 s^-1) | 1 (s^-1) | Kd(af) = 0.527(uM) | - | Substrate: Ca Ca CaNAB-Ca2 Products: CaNAB-Ca4 | This process is probably much more complicated and involves CaM. However, as I can't find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11 |
| 4 | B | PP2B Pathway No. 342 | 2.238 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.4468(uM) | - | Substrate: CaM-Ca3 CaNAB-Ca4 Products: CaMCa3-CaNAB |
| 5 | AB | PP2B Pathway No. 342 | 0.24 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 4.1666(uM) | - | Substrate: CaNAB-Ca4 CaM-TR2-Ca2 Products: CaMCa2-CANAB | Disabled. See notes for PP2B7.g |