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Enzyme List for pathway sGC (Pathway Number 69)
| Molecule Name/ Site Name | Km (uM) | kcat (1/s) | Ratio (k2/k3) | Enzyme Type | Substrate | Product | |
| 1 | Enzyme Activity: kenz Enzyme Molecule: sGCtot | 20 | 25.25 | 4 | explicit E-S complex | GTP | cGMP |
| The range of estimates found in the literature are: Km -> 40 - 150 uM (without NO) 20 - 40 uM (with NO) Vmax -> 10 - 100 nmol/mg/min (wihtout NO) 10 - 40 umol/mg/min (with NO). ----- thru personal correspondence from T. Bellamy, Wolfson Ins. for Biomedical Sciences, UK. NO increases the Vmax of sGC by 100-200 fold, and it has been proposed that this activation occurs subsequent to the binding of NO toa heme moiety on the enzyme. (Stone and Marletta,1995,Biochemistry,34:14668-14674). | |||||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |