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Molecule List for pathway PKA (Pathway Number 196)
| Name | Initial Conc. (uM) | Volume (fL) | Buffered | ||
| 1 | cAMP.R2C2 | 0 | 1000 | No | |
| CoInit was .0624 | |||||
| 2 | cAMP2.R2C2 | 0 | 1000 | No | |
| 3 | cAMP3.R2C2 | 0 | 1000 | No | |
| 4 | cAMP4.R2 | 0 | 1000 | No | |
| Starts at 0.15 for the test of fig 6 in Smith et al, but we aren't using that paper any more. | |||||
| 5 | cAMP4.R2C | 0 | 1000 | No | |
| 6 | cAMP4.R2C2 | 0 | 1000 | No | |
| 7 | inhibited-PKA | 0 | 1000 | No | |
| 8 | PKA-inhibitor | 0.25 | 1000 | No | |
| About 25% of PKA C subunit is dissociated in resting cells without having any noticable activity. Doskeland SO and Ogreid D (1981) Int J Biochem 13(1):1-19 suggest that this is because there is a corresponding amount of inhibitor protein. | |||||
| 9 | R2C2 | 0.5 | 1000 | No | |
| This is the R2C2 complex, consisting of 2 catalytic (C) subunits, and the R-dimer. See Taylor et al (1990) Ann Rev Biochem 59:971-1005 for a review. The Doskeland and Ogreid review is better for numbers. Amount of PKA is about .5 uM. | |||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |