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Accession Type:
Network
Mammalian_cell_
cycle
Growth
CELLDIV
Rb_grp
IE_GRP
CycB_Grp
Cdc20_Grp
Cdh1_grp
E2F
 Molecule
 Reaction
CycA_Grp
CycE_grp
Early_Response_
Genes
Delayed_
Response_Genes
CycD_Grp

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Reaction List for pathway E2F (Pathway Number 1076)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 k22_23_prime1
(s^-1)
0.005
(s^-1)
Keq = 0.005(uM)0.995secE2FAP
E2FA
  k22 is the forward rate of 1 k23_prime is the backward rate of 0.005
2 k22_23_prime.Rb1
(s^-1)
0.005
(s^-1)
Keq = 0.005(uM)0.995secE2FAP.Rb
E2FA.Rb
  k22 is the forward rate of 1 k23_prime is the backward rate of 0.005
3 k2610
(uM^-1 s^-1)
200
(s^-1)
Kd(bf) = 20.0001(uM)-Rb
E2FA
E2FA.Rb
  k26 = 10, k26r =200 Unless k26 = 10000. There is a period in the paper but it may be a typo. The form of the equation is complex, but if k26 is large then there is more E2F:Rb, so that is the forward reaction here.
4 k26_P10
(uM^-1 s^-1)
200
(s^-1)
Kd(bf) = 20.0001(uM)-Rb
E2FAP
E2FAP.Rb
  Same as k26, but acting on the phosph form.


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