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Accession Type:
Network
BDNF_Receptor
Shared_Object_
BDNF_Receptor
TrKB_mod
 Molecule
 Enzyme
 Reaction
PI3K_mod

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Reaction List for pathway TrKB_mod (Pathway Number 1083)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Autophos_TrKB0.02
(s^-1)		0
(s^-1)		--BDNF_TrkB2_clx
BDNF_TrkB2*_clx
2 Dimeriz_TrKB1
(uM^-1 s^-1)		0.02
(s^-1)		Kd(bf) = 0.02(uM)-BDNF_TrkB_clx
TrKB
BDNF_TrkB2_clx
3 Ligand_binding1.0001
(uM^-1 s^-1)		0.05
(s^-1)		Kd(bf) = 0.05(uM)-TrKB
BDNF
BDNF_TrkB_clx
4 LR_cycling0.001
(s^-1)		0.001
(s^-1)		Keq = 1(uM)500sec
  • Int_BDNF_
    TrKB2*_clx
    		• TrKB
    5 LR_Internalize0.01
    (s^-1)    		0
    (uM^-1 s^-1)    		--BDNF_TrkB2*_clx
  • Int_BDNF_
    TrKB2*_clx
  • Int_BDNF_
    TrKB2*_clx
    • 6 PLC_g*_
    dephospho    		0.07
    (s^-1)    		0
    (s^-1)    		--PLC_g*
    		PLC_g


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    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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