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Accession Type:
Network
BDNF_Receptor
Shared_Object_
BDNF_Receptor
TrKB_mod
PI3K_mod
 Molecule
 Enzyme
 Reaction

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Reaction List for pathway PI3K_mod (Pathway Number 1084)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 basal_PI3K_act0.0007
(s^-1)		0.45
(s^-1)		Keq = 661.7647(uM)2.219secPI3K
PI3K_basal
2 bind_Gab10.3
(uM^-1 s^-1)		1
(s^-1)		Kd(bf) = 3.3333(uM)-Gab1
Shc*_Grb2_clx
  • Shc*_Grb2-Gab1_
    clx
    • 3 Grb2_bind_Shc1
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 1(uM)-Grb2
    Shc*
    		Shc*_Grb2_clx
    4 PI3K_act5.0002
    (uM^-1 s^-1)    		0.08
    (s^-1)    		Kd(bf) = 0.016(uM)-PI3K
  • Shc*_Grb2-Gab1_
    clx
  • Shc*_Grb2-Gab1_
    PI3K_clx
    • 5 Shc*_dephospho0.2
    (s^-1)    		0
    (s^-1)    		--Shc*
    		Shc


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    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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