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Accession Type:
Pathway
MAPK_Asthagiri_
no_fb
MAPK_Asthagiri_
no_fb
 Molecule
 Enzyme
 Reaction

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Reaction List for pathway MAPK_Asthagiri_no_fb (Pathway Number 192)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 A1-bind-A25.0001
(uM^-1 s^-1)		0.5
(s^-1)		Kd(bf) = 0.1(uM)-A2
A1
A1A2
  Kc12 and Kd12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001.
2 C*-bind-A15.0001
(uM^-1 s^-1)		0.5
(s^-1)		Kd(bf) = 0.1(uM)-C*
A1
C*A1
  Kf1 is 3*10^8 M-1 min-1 and Kr1 is 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
3 C*-bind-A1A25.0001
(uM^-1 s^-1)		0.5
(s^-1)		Kd(bf) = 0.1(uM)-A1A2
C*
E0*
  Kf12 and Kr12 are 3*10^8 M-1 min-1 and 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
4 C*A1-bind-A25.0001
(uM^-1 s^-1)		0.5
(s^-1)		Kd(bf) = 0.1(uM)-C*A1
A2
E0*
  kf2 and kr2 are 3*10^8 M-1 min-1 and 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
5 C-dimer1
(uM^-1 s^-1)		1
(s^-1)		Keq = 1(uM)-C
C
C2
  Kc is 6*10^7 M-1 min-1 and Ku is 60 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
6 C2-phos0.833
(s^-1)		0.0833
(s^-1)		Keq = 0.1(uM)1.091secC2
C*
  Kc+ is 50min-1 and Kc- is 5min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
7 L-bind-R0.1666
(uM^-1 s^-1)		0.005
(s^-1)		Kd(bf) = 0.03(uM)-L
R
C
  Kf = 10^7/M-1 min-1 and Kr is 0.3 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39


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