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Molecule List for pathway Sos (Pathway Number 337) in Accession Ajay_Bhalla_2004_PKM_MKP3_Tuning (Accession Number 77) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering. arrow indicates that ordering is done according to ascending or descending order. The entries are grouped according to Pathway Number and are alternately color coded using and color. |
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Name![](database/fig/up.png) | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | 1 | Grb2 | Network | 1 | 0 | No | - | | There is probably a lot of it in the cell: it is also known as Ash (abundant src homology protein I think). Also Waters et al JBC 271:30 18224 1996 say that only a small fraction of cellular Grb is precipitated out when SoS is precipitated. As most of the Sos seems to be associated with Grb2, it would seem like there is a lot of the latter. Say 1 uM. I haven't been able to find a decent.... | 2 | Sos | Network | 0.1 | 0 | No | - | | I have tried using low (0.02 uM) initial concs, but these give a very flat response to EGF stim although the overall activation of Ras is not too bad. I am reverting to 0.1 because we expect a sharp initial response, followed by a decline. Sep 17 1997: The transient activation curve looks better with [Sos] = 0.05. Apr 26 1998: Some error there, it is better where it was at 0.1 | 3 | Sos* | Network | 0 | 0 | No | - | 4 | Sos*.Grb2 | Network | 0 | 0 | No | - | 5 | Sos.Grb2 | Network | 0 | 0 | No | - |
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